Determinants of potency and temperature-dependent function in the Aplysia bag cell peptides

Add time:08/04/2019    Source:sciencedirect.com

Structure-activity relationships were determined for the natural bag cell peptides (BCPs) and for a series of synthetic analogues in terms of their ability to stimulate (at 30°C) and to inhibit (at 15°C) bag cell adenyl cyclase. We found that the core RLRF motif shared by all these peptides is active in this assay, and is stimulatory. The histidine residue C-terminal to this motif in β-BCP is superfluous in this respect. An electronegative residue C-terminal to RLRF is sufficient to induce temperature-dependent function. The Ala-Pro pair that is N-terminal to this motif in α-BCP increases potency, but does not alter function.

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