Salicylate release from a polypyrrole matrix

Add time:08/01/2019    Source:sciencedirect.com

Salicylate release from a microstructured polypyrrole coating with a large surface area was investigated. The drug was incorporated as a dopant in the polymer matrix via electropolymerization of pyrrole in a simple one-step process. The influence of several parameters such as applied potential and hydrodynamic conditions on the releasing behavior was studied. Once the drug has been delivered from the polymeric matrix, the electrode can be reloaded with salicylate for later release. The amount of eluted salicylate was effective in inhibiting albumin denaturation which is associated with antiinflammatory effects.

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