Triphenylphosphine: An efficient catalyst for the synthesis of 4,6-diphenyl-3,4-dihydropyrimidine-2(1H)-thione under thermal conditions

Add time:08/03/2019    Source:sciencedirect.com

An efficient and direct procedure for the synthesis of 4,6-diphenyl-3,4-dihydropyrimidine-2(1H)-thione derivatives by condensation of 1,3-diaryl-2-propen-1-ones (chalcones) and thiourea in ethanol at 65 °C using triphenylphosphine (PPh3) as a catalyst is reported. The method gave good yields of 4,6-diphenyl-3,4-dihydropyrimidine-2(1H)-thione derivatives in short reaction times in comparison with earlier methods. The catalyst is recycled without loss of activity. Using non-toxic and inexpensive materials, simple work-up, short reaction times and high yields of the products are the advantages of this method.

We also recommend Trading Suppliers and Manufacturers of 1,3-Diphenyl-2-thiourea (cas 102-08-9). Pls Click Website Link as below: cas 102-08-9 suppliers

Prev:Reactions of P4S10 and pyPS2Cl with N,N′-diphenylurea and N,N′-diphenylthiourea
Next:Difference in the developmental toxicity of ethylenethiourea and three N,N′-substituted thiourea derivatives in rats)