Difference in the developmental toxicity of ethylenethiourea and three N,N′-substituted thiourea derivatives in rats

Add time:08/04/2019    Source:sciencedirect.com

Sprague-Dawley rats were administered ethylenethiourea (ETU), 1,3-dimethyl-2-thiourea (DMT), 1,3-dibutyl-2-thiourea (DBT), or 1,3-diphenyl-2-thiourea (DPT) by gavage from Days 6 to 20 of gestation. Daily dosage levels (mg/kg/day) were ETU at 0, 15, 25, and 35; DMT at 0, 15, 25, 50, 100, and 200; DBT at 0, 15, 25, 50, 100, and 200; and DPT at 0, 25, 50, 100, and 200. There was evidence of maternal toxicity at all doses of DMT and at doses ≥ 50 mg DBT/kg/day. DPT was embryolethal at 200 mg/kg/day. Fetotoxicity was observed at doses ≥ 15 mg DMT/kg/day, ≥ 15 mg DBT/kg/day, and ≥ 100 mg DPT/kg/day/ ETU was the only chemical tested that proved to be teratogenic.

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