N-Dibenzylphospho-N′-3-(2,6-dichlorophenyl)propyl-guanidine is a bisubstrate-analog for creatine kinase
-
Add time:07/14/2019 Source:sciencedirect.com
We describe a new compound, N-dibenzylphospho-N′-3-(2,6-dichlorophenyl)-propylguanidine (DPPG), and our study of its interaction with cytosolic CK. To our knowledge, it is the most potent inhibitor known for CK: the Ki value versus ADP was 330 nM and 110 nM for CK-MM and BB respectively. In view of the inhibition pattern, Ki(app) dependencies on the second substrate, and very low Ki values, we conclude that DPPG binds to the active site as a bisubstrate-type analog. This bisubstrate analog confirms different mechanisms for CK-MM and BB: in spite of a more than 80% similarity in amino-acid sequences, both isoenzymes are random at pH 8.6 but CK-BB has an ordered mechanism at pH 6.6.
We also recommend Trading Suppliers and Manufacturers of N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride (cas 7555-15-9). Pls Click Website Link as below: cas 7555-15-9 suppliers
Prev:Tremorogenesis by LON-954 [N-carbamoyl-2-(2,6-dichlorophenyl) acetamidine hydrochloride]: Evidence for the involvement of 5-hydroxytryptamine
Next:Structural properties and FTIR-Raman spectra of the anti-hypertensive clonidine hydrochloride agent and their dimeric species) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Synthesis and Antimicrobial Activity of 2-[2-(2,6-dichloro phenyl) amino]benzyl-3-(5-substituted phenyl-4,5-dihydro-1H-pyrazol-3-yl-amino)-6,8-dibromoquinazolin-4(3H)ones07/19/2019
- Calorimetric and spectroscopic characterization of complexes between β-cyclodextrin or heptakis (2,6-di-O-methyl)-β-cyclodextrin and sertraline hydrochloride in aqueous solution07/18/2019
- Diels–Alder cycloaddition of 2-azadienes to methyl 2-(2,6-dichlorophenyl)-2H-azirine-3-carboxylate in the synthesis of methyl 4-oxo-1,3-diazabicyclo[4.1.0]heptane-6-carboxylates07/17/2019
- Identification of N-Hydroxycinnamamide analogues and their bio-evaluation against breast cancer cell lines07/16/2019
- Structural properties and FTIR-Raman spectra of the anti-hypertensive clonidine hydrochloride agent and their dimeric species07/15/2019
- Tremorogenesis by LON-954 [N-carbamoyl-2-(2,6-dichlorophenyl) acetamidine hydrochloride]: Evidence for the involvement of 5-hydroxytryptamine07/13/2019
- α2-antagonistic effect of N-carbamoyl-2-(2,6-dichlorophenyl) acetamidine hydrochloride (LON-954)07/12/2019
- Pharmacological profile of N-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide, a novel analogue of lidocaine07/11/2019
