Calorimetric and spectroscopic characterization of complexes between β-cyclodextrin or heptakis (2,6-di-O-methyl)-β-cyclodextrin and sertraline hydrochloride in aqueous solution

Add time:07/18/2019    Source:sciencedirect.com

The interaction of sertraline hydrochloride (SRT) with β-cyclodextrin (β-CD) and heptakis(2,6-di-O-methyl)-β-cyclodextrin (DM-β-CD) in aqueous solutions was investigated using the methods of isothermal titration calorimetry (ITC), nuclear magnetic resonance (1H NMR) and UV–Vis spectroscopy. The interaction parameters, such as the association constant, enthalpy, entropy and Gibbs energy of complexation of SRT by β-CD and DM-β-CD in water at T = 298.15 K have been evaluated. Both enthalpic and entropic effects make a contribution to SRT association with β-CD or DM-β-CD.

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