Effects of leucomyosuppressin (cas 106884-19-9) on the excitation-concentration coupling of insect Leucophaea maderae visceral muscle
-
Add time:08/11/2019 Source:sciencedirect.com
1. leucomyosuppressin (cas 106884-19-9) (LMS) inhibited neurally evoked contractions of the hindgut of the cockroach Leucophaea maderae. The threshold for this inhibition of LMS was in the range of 1 × 10−10 M.2. LMS caused a sharp reduction in both l-glutamate and proctolin induced contractions. Dose-response profiles of the effect of LMS (held constant at 10−8M) on variable amounts of proctolin showed an inhibitory effect at 10−9 M proctolin and below, but at 5 × 10−9 M proctolin and above, LMS caused no inhibition.3. Potassium (158 mM) depolarized hindguts treated with LMS (10−8 M) showed a marked reduction (76% ± 2.1) in the proctolin (10−8 M) response.4. When calcium depleted preparations were returned to normal calcium levels (2 mM) in the presence of proctolin (10 −8 M) a contraction occurred that was 45% ± 4 of the maximum in normal saline solution. However, LMS (10−8 M) reduced this response to only 28% ± 2 of the maximum.5. Proctolin (10−8 M) induced contractions in the presence of the manganous ions (2mM) fell to 63% ± 4 of the maximum but on the addition of LMS (10−8M), such responses fell to only 16% ± 5 of the maximum.6. These results offer evidence for a non-synaptic site of action for LMS and a perturbation of key calcium dependent events in the excitation-contraction coupling sequence of visceral muscle by this peptide.
We also recommend Trading Suppliers and Manufacturers of leucomyosuppressin (cas 106884-19-9). Pls Click Website Link as below: cas 106884-19-9 suppliers
Prev:Comparative effects of leucomyosuppressin (cas 106884-19-9) on the visceral muscle systems of the cockroach Leucophaea maderae
Next:Isolation, primary structure and synthesis of leucomyosuppressin (cas 106884-19-9), an insect neuropeptide that inhibits spontaneous contractions of the cockroach hindgut) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- The muscular contractions of the midgut of the cockroach, Diploptera punctata: effects of the insect neuropeptides proctolin and leucomyosuppressin (cas 106884-19-9)08/14/2019
- leucomyosuppressin (cas 106884-19-9), a novel insect neuropeptide, inhibits evoked transmitter release at the mealworm neuromuscular junction08/13/2019
- Isolation, primary structure and synthesis of leucomyosuppressin (cas 106884-19-9), an insect neuropeptide that inhibits spontaneous contractions of the cockroach hindgut08/12/2019
- Comparative effects of leucomyosuppressin (cas 106884-19-9) on the visceral muscle systems of the cockroach Leucophaea maderae08/10/2019
- Degradation of leucomyosuppressin (cas 106884-19-9) by enzymes in the hemolymph and midgut of Lacanobia oleracea and Spodoptera littoralis (Lepidoptera: Noctuidae) larvae08/09/2019
- Identification of leucomyosuppressin (cas 106884-19-9) in the German cockroach, Blattella germanica, as an inhibitor of food intake08/08/2019
- Characterization of the gene for leucomyosuppressin (cas 106884-19-9) and its expression in the brain of the cockroach Diploptera punctata08/07/2019
- The cDNA for leucomyosuppressin (cas 106884-19-9) in Blattella germanica and molecular evolution of insect myosuppressins08/06/2019
- leucomyosuppressin (cas 106884-19-9) modulates cardiac rhythm in the cockroach Blattella germanica08/05/2019