Isolation, primary structure and synthesis of leucomyosuppressin (cas 106884-19-9), an insect neuropeptide that inhibits spontaneous contractions of the cockroach hindgut

Add time:08/12/2019    Source:sciencedirect.com

1. A neuropeptide that inhibits spontaneous contractions of the isolated cockroach hindgut was purified from head extracts of the cockroach, Leucophaea maderae.2. The inability of aminopeptidase M to degrade the peptide and the presence of glutamic acid in the hydrolysate suggested N-terminal blocking by pyroglutamic acid. The N-terminal pGlu was removed enzymatically and the unblocked fragment was sequenced with an automated peptide sequencer.3. The structure determined (pGlu-Asp-Val-Asp-His-Val-Phe-Leu-Arg-Phe-NH2) was synthesized and shown to be both chemically and biologically identical with the natural product.4. Leucomyosuppressin is the first inhibitory neuropeptide isolated and structurally identified from an insect source.

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