Synthesis of α-hydroxy statine through a facially selective osmylation of a chiral α-amido crotonate

Add time:08/09/2019    Source:sciencedirect.com

α-hydroxy statine 5 was synthesized by osmylation of amido crotonate 6 and incorporated into peptide framework 9, resulting in an active renin inhibitor; predicted stereochemical preferences for renin inhibition were confirmed by x-ray analysis and biochemical determinations. The facial selectivity of the osmylation is consistent with the Vedejs model.

We also recommend Trading Suppliers and Manufacturers of Cyclohexyl crotonate (cas 16491-62-6). Pls Click Website Link as below: cas 16491-62-6 suppliers

Prev:Synthesis of the C1–C12 acid fragment of amphidinolide T marine macrolides via SmI2-mediated enantioselective reductive coupling of aldehydes with a chiral crotonate
Next:Straightforward synthesis of [(2S,4R)-1-cyclohexyl-4-methylpiperidin-2-yl]methanol and [(2S,4R)-1-cyclohexyl-4-methylpiperidin-2-yl](diphenyl)methanol: novel chiral ligands for the catalytic addition of diethylzinc to benzaldehyde to give rise to an extensive turn in the sense of asymmetric induction)