2-Hydroxyethyl substituted NHC precursors: Synthesis, characterization, crystal structure and carbonic anhydrase, α-glycosidase, butyrylcholinesterase, and acetylcholinesterase inhibitory properties

Add time:07/14/2019    Source:sciencedirect.com

This study contains novel a serie synthesis of N-heterocyclic carbene (NHC) precursors that 2-hydroxyethyl substituted. The NHC precursors have been prepared from 1-(2- hydroxyethyl)benzimidazole and alkyl halides. The novel NHC precursors have been characterized by using 1H NMR, 13C NMR, FTIR spectroscopy and elemental analysis techniques. Molecular and crystal structures of 2a, 2d, 2e, 2f and 2g were obtained with single-crystal X-ray diffraction studies. These novel NHC precursor's derivatives effectively inhibited the α-glycosidase, cytosolic carbonic anhydrase I and II isoforms (hCA I and II), butyrylcholinesterase (BChE) and acetylcholinesterase (AChE). Inhibition constant (Ki) were found in the range of 0.30–9.22 nM for α-glycosidase, 13.90–41.46 nM for hCA I, 12.82–49.95 nM for hCA II, 145.82–882.01 nM for BChE, and 280.92–1370.01 nM for AChE, respectively.

We also recommend Trading Suppliers and Manufacturers of 2-[(2-hydroxyethyl)(methyl)amino]ethyl acetate (cas 40066-89-5). Pls Click Website Link as below: cas 40066-89-5 suppliers

Prev:PEGylation controls attachment and engulfment of monodisperse magnetic poly(2-hydroxyethyl methacrylate) microspheres by murine J774.2 macrophages
Next:Electron impact ionization and ion–molecule reactions of OCTAFLUORO-2-BUTENE (cas 360-89-4))