alpha-methyltryptophan (cas 13510-08-2): Effects on synthesis and degradation of serotonin in the brain

Add time:08/12/2019    Source:sciencedirect.com

Alpha-methyltryptamine and α-methylserotonin have been detected in the brain following the administration of doses of AMTP (α-methyltryptophan) of 50 mg/kg or greater. At 4–6 hr after a single injection of AMTP the concentration of α-methyltryptamine was very much smaller than that of α-methylserotonin. The concentration of the latter substance was followed as a function of time after the administration of AMTP. There was a gradual increase of α-methylserotonin and decrease of serotonin so that the concentration of α-methyl-serotonin rose to 6 times that of the naturally occurring amine in 48 hr, falling to 3 times its concentration in 96 hr. Control levels of 5-hydroxyindoleacetic acid and of material measured fluorometrically as serotonin were eventually attained 8–10 days after the injection of AMTP.The influence of AMTP on the concentrations of brain 5-hydroxyindoleacetic acid and serotonin-like substances (i.e. serotonin and α-methylserotonin) was studied in relation to the actions of various drugs. Treatment of rats with sufficient p-chlorophenylalanine to lower the concentration of serotonin and 5-hydroxyindoleacetic acid in the brain by 50% did not prevent the appearance of substantial amounts of α-methylserotonin in the brains of AMTP-treated animals. On the other hand, the decarboxylase inhibitors Ro4-4602 and NSD-1055, both prevented formation of α-methylserotonin from AMTP. Reserpine, 2 monoamine oxidase inhibitors, and probenecid were also tested for interaction with AMTP. The results with respect to cerebral 5-hydroxyindoleacetic acid were generally interpretable on the basis of independent actions of the drugs.

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