Metabolism of α-methyltryptophan
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Add time:08/13/2019 Source:sciencedirect.com
The metabolism of α-methyltryptophan was studied in the rat. The α-methylamino acid was measured by colorimetrie and radioactive methods (the latter used for tritium-labeled material) at various time intervals after its intraperitoneal injection. The specific uptake (μgg organ) was highest in the kidneys, pancreas, and intestinal tract. The amino acid was detectable in these organs, as well as in the liver and plasma, for at least four days. There were low concentrations in the brain, spleen, heart, and lungs. α-Methyltryptophan caused an increased excretion of kynurenic and xanthurenic acids for two days after its administration, thus displaying an effect on the metabolism of endogenous tryptophan.
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