Anti Aldol reactions of α-alkoxymethyl ketones: Application to the total synthesis of (+)-Restricticin (cas 135357-96-9)

Add time:08/12/2019    Source:sciencedirect.com

The antifungal agent (+)-restricticin (1) was prepared in 12 steps from ketone (S)-8. The key steps are (i) the boron-mediated anti aldol reaction of (S)-8 with 9 to give 13 and (ii) the cyclisation reaction 4 → 15.

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