Structure elucidation of Restricticin (cas 135357-96-9), a novel antifungal agent from penicillium restrictum

Add time:08/13/2019    Source:sciencedirect.com

The structures and absolute stereochemistry of restricticin (1), its N,N-dimethyl derivative (4) and desglycyl hydrolysis product (3), isolated from Penicillium restrictum, have been determined on the basis of spectroscopic evidence. They belong to a new class of broad spectrum antifungal agents representing substituted tetrahydropyranyl ethers incorporating triene and glycyl ester side chains.

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