Determination of 7-methylbenz[c]acridines by capillary gas chromatography with electron-capture detection

Add time:07/13/2019    Source:sciencedirect.com

A sensitive gas chromatographic procedure for the determination of 7-methylbenz[c]acridines (7-methyl-BAcs) is presented. The 7-methyl-BAcs are easily oxidized to 7-formylbenz[c]-acridines (7-formyl-BAcs) with periodic acid in dimethyl sulfoxide. The 7-formyl-BAcs are then reacted directly with p-fluoroaniline by way of Schiff base formation. The Schiff bases are analyzed by gas chromatography using a 25-m HP-5 column with electron-capture detection. The electron-capture response for the Schiff bases is very sensitive and amounts down to 20 pg are easily detected. Mass spectral data for the Schiff bases obtained under electron inpact conditions are also presented.

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