Studies in the metabolism of carcinogenic polycyclic heteroaromatic compounds

Add time:07/15/2019    Source:sciencedirect.com

An enzyme assay for the metabolism of the carcinogenic aza-aromatic polycyclic compound 7-methylbenz[c]acridine has been developed using a modification of a radiochemical assay described for the polycyclic aromatic hydrocarbon benzo[a]pyrene by DePierre et al. [J. W. DePierre, M. S. Moron, K. A. M. Johannesen and L. Ernster, Analyt. Biochem. 63, 470 (1975)]and Van Cantfort et al. [J. Van Cantfort, J. DeGraeve and J. E. Gielen, Biochem. biophys. Res. Commun. 79, 505 (1977)]. When the activities of control microsomes and microsomes of phenobarbital-, 3-methylcholanthrene-and 7-methylbenz[c]acridine-pretreated animals were compared, strong similarities were displayed toward oxidation of benzo[a]pyrene and 7-methylbenz[c]acridine. These similarities were seen in turnover numbers, Michaelis constants, and inducibility of both enzyme systems. 7-Methylbenz[c]acridine afforded a type I difference spectrum with 3-methylcholanthrene-pretreated microsomes. It is suggested that 7-methylbenz[c]acridine is oxidized by the same or a similar set of enzymes which is responsible for benzo[a]pyrene metabolism.

We also recommend Trading Suppliers and Manufacturers of 7-methylbenz(c)acridine (cas 3340-94-1). Pls Click Website Link as below: cas 3340-94-1 suppliers

Prev:Potential metabolites of carcinogenic aza aromatic hydrocarbons synthesis of K-region oxide, phenol and dihydrodiols of 7-methylbenz[c]acridine
Next:Reaktionen von 2H-isoindolen mit aktivierten azo-verbindungen)