Synthesis of substituted tropones by sequential Rh-catalyzed [5+2] cycloaddition and elimination

Add time:08/16/2019    Source:sciencedirect.com

Highly substituted tropones are prepared from cycloheptatrienes derived from Rh-catalyzed intermolecular [5+2] cycloaddition of 3-acyloxy-1,4-enynes and propargylic alcohols. The intermolecular [5+2] cycloaddition is highly regioselective for a variety of propargylic alcohols. Elimination of the cycloaddition products afforded various substituted tropones.

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