Biosynthesis of the neurotoxin β-N-oxalyl-α,β-diaminopropionic acid in callus tissue of Lathyrus sativus

Add time:08/18/2019    Source:sciencedirect.com

The biosynthesis of the neurotoxic amino acid β-N-oxalyl-l-α,β-diaminopropionic acid (ODAP) can be induced in the callus tissues of Lathyrus sativus by supplying β-(isoxazolin-5-on-2-yl)-alanine (BIA) in the liquid medium. When [14C]BIA is supplemented with free α,β diaminopropionic acid (DAPRO) the incorporation of [14C] into ODAP shows a concentration dependent inhibition. The incorporation is stimulated when [14C]BIA is supplemented with oxalate. This confirms the previous finding that BIA is the precursor for ODAP and indicates that DAPRO may indeed be the short-lived intermediate in this pathway.

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