Transdermal delivery of Betahistine Hydrochloride (cas 15430-48-5) using microemulsions: Physical characterization, biophysical assessment, confocal imaging and permeation studies
-
Add time:08/18/2019 Source:sciencedirect.com
Transdermal delivery of Betahistine Hydrochloride (cas 15430-48-5) encapsulated in various ethyl oleate, Capryol 90®, Transcutol® and water microemulsion formulations was studied. Two different kinds of phase diagrams were constructed for the investigated microemulsion system. Pseudoplastic flow that is preferable for skin delivery was recorded for the investigated microemulsions. A balanced and bicontinuous microemulsion formulation was suggested and showed the highest permeation flux (0.50 ± 0.030 mg cm−2 h−1). The effect of the investigated microemulsions on the skin electrical resistance was used to explain the high permeation fluxes obtained. Confocal laser scanning microscopy was used to confirm the permeation enhancement and to reveal the penetration pathways. The results obtained suggest that the proposed microemulsion system highlighted in the current work can serve as a promising alternative delivery means for betahistine hydrochloride.
We also recommend Trading Suppliers and Manufacturers of Betahistine Hydrochloride (cas 15430-48-5). Pls Click Website Link as below: cas 15430-48-5 suppliers
Prev:Highly sensitive and selective polyaniline–zinc oxide nanocomposite sensor for Betahistine Hydrochloride (cas 15430-48-5) in solubilized system
Next:Utilization of carbon disulphide for the analytical determination of Betahistine Hydrochloride (cas 15430-48-5) and captopril in their pharmaceutical preparations) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Actions of betahistine at histamine receptors in the brain08/24/2019
- Betahistine increases vestibular blood flow☆☆☆08/23/2019
- Stress degradation studies on betahistine and development of a validated stability-indicating assay method08/22/2019
- Extraction of chitosan from Aspergillus niger mycelium and synthesis of hydrogels for controlled release of betahistine08/21/2019
- Role of capillary pericytes and precapillary arterioles in the vascular mechanism of betahistine in a guinea pig inner ear model08/20/2019
- Utilization of carbon disulphide for the analytical determination of Betahistine Hydrochloride (cas 15430-48-5) and captopril in their pharmaceutical preparations08/19/2019
- Highly sensitive and selective polyaniline–zinc oxide nanocomposite sensor for Betahistine Hydrochloride (cas 15430-48-5) in solubilized system08/17/2019
- Effect of drug-ion exchange resin complex in Betahistine Hydrochloride (cas 15430-48-5) orodispersible film on sustained release, taste masking and hygroscopicity reduction08/16/2019
-
Health and Chemical more >