Organocatalytic peroxidation of malonates, β-ketoesters, and cyanoacetic esters using n-Bu4NI/t-BuOOH-mediated intermolecular oxidative C(sp3)–O coupling

Add time:08/18/2019    Source:sciencedirect.com

A new organocatalytic approach for the synthesis of peroxides based on СН activation of a sp3-hybridized carbon atom is reported. Peroxides were prepared in 31–89% yield by the reaction of malonates, β-ketoesters, and cyanoacetic esters with a Bu4NI/tert-butyl hydroperoxide system. The formation of the expected hydroxylation products was not observed. In the discovered reaction, tert-butyl hydroperoxide plays a dual role by acting as the oxidant and the O-reagent for the C–O coupling. The synthesis can be scaled up to generate gram quantities of the target products.

We also recommend Trading Suppliers and Manufacturers of DIETHYL 2-(2-CYANOETHYL)MALONATE (cas 17216-62-5). Pls Click Website Link as below: cas 17216-62-5 suppliers

Prev:Antiinflammatory β-benzeneethanamines. III
Next:Supramolecular organization in lead(II) halides of 4,4′-dimethoxy-2,2′-bipyridine ligand)