IatrogénieToxicité rénale du méthotrexate à haute doseRenal toxicity of high-dose methotrexate
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Add time:08/23/2019 Source:sciencedirect.com
RésuméIntroductionLe méthotrexate à haute dose (supérieure ou égale à 1 g/m2) est utilisé pour traiter certaines hémopathies malignes et ostéosarcomes. La survenue d’une insuffisance rénale aiguë est une complication classique qui favorise le retard d’élimination du méthotrexate et ses diverses toxicités. Au-delà des mesures thérapeutiques classiques (hyperhydratation alcaline, acide folinique, épuration extrarénale), une enzymothérapie spécifique onéreuse est disponible (glucarpidase) mais son impact clinique est mal évalué.
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