Inactivation of cathepsin B1 by diazomethyl ketones
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Add time:08/24/2019 Source:sciencedirect.com
Benzyloxycarbonyl-phenylalanyl diazomethyl ketone and benzyloxy-carbonyl-phenylalanyl-phenylalanyl diazomethyl ketone, which have been shown to inactivate the thiol protease papain by a mechanism different from that of substrate chloromethyl ketone derivatives, have now been examined as inhibitors of cathepsin B1 of beef spleen. The dipeptide derivative irreversibly inactivates this protease rapidly, apparently by affinity labeling.
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