Inhibitory effects of dissolved organic matter on Erythromycin (cas 114-07-8) bioavailability and possible mechanisms

Add time:08/26/2019    Source:sciencedirect.com

Macrolides are widely used antibiotics with ubiquitous occurrence in aquatic environments. Unlike many emerging contaminants, macrolides are positively charged on their amine groups and are likely to interact with negative charge groups of dissolved organic matters (DOMs), which may alter macrolide bioaccumulation but yet to be explored. Here we evaluated the effects of different DOM (LeHA, PPHA, SRHA and SRFA) on Erythromycin (cas 114-07-8) (an important macrolide) bioaccumulation into aquatic biota with 14C tracing. Results showed that ERY uptake in organisms was significantly inhibited by DOM (P < 0.05). In the presence of DOM at 20 mg L−1, the averaged equilibrium concentration (Ce) decreased by 28.1–40.6% for zebrafish and 10.9–25.8% for duckweed, corresponding to reductions in the bioconcentration factor (BCF) by 15.9–32.8% and 10.9–18.5%, respectively. Likely due to their higher carboxyl group content, SRHA and SRFA exhibited stronger inhibitory effects than LeHA or PPHA. The possible interactions between ERY and DOM were explored and results suggested that DOM inhibited ERY bioavailability by forming DOM-ERY complexes via ionic bonding of −COO− and ERY+, hydrogen bonding and hydrophobic partitioning. This study was the first to report on inhibitory effects of DOM on erythromycin bioavailability and has important implications for better understanding risks of macrolides.

We also recommend Trading Suppliers and Manufacturers of Erythromycin (cas 114-07-8). Pls Click Website Link as below: cas 114-07-8 suppliers

Prev:Original ResearchObstetricsAzithromycin vs Erythromycin (cas 114-07-8) for the management of preterm premature rupture of membranes
Next:Bioinspired Pt-free molecularly imprinted hydrogel-based magnetic Janus micromotors for temperature-responsive recognition and adsorption of Erythromycin (cas 114-07-8) in water)