Long-term exposure to cypermethrin and Piperonyl Butoxide (cas 19510-30-6) cause liver and kidney inflammation and induce genotoxicity in New Zealand white male rabbits

Add time:08/24/2019    Source:sciencedirect.com

Cypermethrin (CY) is a frequently used class II pyrethroid pesticide, while Piperonyl Butoxide (cas 19510-30-6) (PBO) plays a major role in the pesticide formulation of synthetic pyrethroids. Synthetic pyrethroids are metabolized in mammals via oxidation and ester hydrolysis. PBO can prevent the metabolism of CY and enhances its pesticide effect. While this potentiation effect reduces the amount of pesticide required to eliminate insects, it is not clear how this mixture affects mammals. In our in vivo experiment, New Zealand white male rabbits were exposed to low and high doses of CY, PBO, and their combinations, for 4 months. Genotoxicity and cytotoxicity were monitored by measuring binucleated cells with micronuclei (BNMN), micronuclei (MN) and the cytokinesis block proliferation index (CBPI) in lymphocytes. After two months of exposure, a statistically significant increase in the frequency of BNMN was observed for all exposed animals (p < 0.001) in a dose-dependent way. MN were significantly elevated compared to controls (p < 0.001), with high dose groups reaching a 442% increase when co-exposed. BNMN and MN continued to increase after four months. Histopathological examination of lesions showed damage involving inflammation, attaining lymphoplasmatocytic infiltration in the high dose groups. Both CY and PBO cause liver and kidney inflammation and induce genotoxicity.

We also recommend Trading Suppliers and Manufacturers of Piperonyl Butoxide (cas 19510-30-6). Pls Click Website Link as below: cas 19510-30-6 suppliers

Prev:Downgrading the systemic condition of rabbits after long term exposure to cypermethrin and Piperonyl Butoxide (cas 19510-30-6)
Next:Prenatal exposure to pesticide ingredient Piperonyl Butoxide (cas 19510-30-6) and childhood cough in an urban cohort☆)