Oxidative and apoptotic effects of lambda-cyhalothrin modulated by Piperonyl Butoxide (cas 19510-30-6) in the liver of Oreochromis niloticus

Add time:08/30/2019    Source:sciencedirect.com

The aim of this study was to investigate the toxic effects of pyrethroid pesticide lambda-cyhalothrin in the presence of Piperonyl Butoxide (cas 19510-30-6) as a modulator in the liver of juvenile Oreochromis niloticus. LC50 (96 h) value of lambda-cyhalothrin was determined as 2.901 μg/L for O. niloticus. The fish were exposed to 0.48 μg/L (1/6 of the 96-h LC50) lambda-cyhalothrin and 10 μg/L piperonyl butoxide for 96-h and 15-d. tGSH, GSH, GSSG, Hsp70 and TBARS contents, GPx, GR, GST and caspase-3 enzymes activities were determined. Lambda-cyhalothrin caused increases in tGSH, GSH, TBARS contents, and GST activity. Piperonyl butoxide treatment with lambda-cyhalothrin caused significant increases in tGSH GSH, Hsp70, TBARS contents, and GPx and GST activities while caspase-3 activity was decreased. The results of the present study revealed that lambda-cyhalothrin caused oxidative stress which upregulated GSH and GSH-related enzymes. Piperonyl butoxide increased the oxidative stress potential and apoptotic effects of lambda-cyhalothrin.

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