A Coenzyme A analogue, Desulpho-CoA; Preparation and effects on various enzymes

Add time:08/29/2019    Source:sciencedirect.com

The binding of Coenzyme A and its acyl derivatives to carnitine acetyltransferase (EC 2.3.1.7) has been studied in this Department as part of an investigation into the mechanism of action of this enzyme. A CoA analogue lacking the reactive -SH group was needed for this work, and such an analogue would also have general use as a CoA antagonist. The present paper describes the preparation and analysis of desulpho-CoA, in which the thiol group is replaced by hydrogen. The results of a preliminary survey of the effects of this compound on various enzymes are also given.

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