NotesComparison of Effects of 1,8-Dihydroxyanthraquinone (cas 117-10-2) and 1,5-Dihydroxyanthraquinone on Different Segments of Rabbit Gastrointestinal Tract

Add time:08/29/2019    Source:sciencedirect.com

Using an isolated muscle bath technique, five different segments of the rabbit gastrointestinal tract (duodenum, jejunum, ileum, and ascending and descending colon) were used to record the effects of two doses of 1,5-dihydroxyanthraquinone. Transducer-recorded tracings were made of contractions per minute, interval between contractions, and amplitude of contractions. The results were evaluated; statistical tests among comparisons of the three parameters between the two drug doses, control values, and previous values for 1,8-Dihydroxyanthraquinone (cas 117-10-2) again indicated the parameter of interval between contractions to be a statistically significant measurement of activity. No statistically significant differences in effects were shown between the two drugs.

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