The effects of 1-(1-Phenylcyclohexyl) piperidine HCl (Sernylan) on bulbospinal and spinal reflexes

Add time:08/28/2019    Source:sciencedirect.com

We have investigated the effects of Sernylan, a dissociative anaesthetic, on both the bulbo-spinal and spinal reflexes of cats. Cats decerebrated at the precollilcular level were used to investigate the interaction of bulbo-spinal with spinal reflexes. Conditioning stimuli were delivered to the contralateral dorsal root, reticular formation, or medial longitudinal fasciculus and their effect on the amplitude of the test monosynaptic reflex at L7 was recorded. Sernylan (2 mgkg, i.v.) decreased the amplitude of the test monosynaptic reflex and decreased or totally eliminated both the facilitation and the inhibition phases of the spino-bulbo-spinal response pattern, but had little effect at this dosage on bulbo-spinal interactions with the monosynaptic reflex (whether conditioning was delivered to the reticular formation or medial longitudinal fasciculus). Spinal reflexes were investigated in cats made spinal at T10. Sernylan (1–2 mgkg) in spinal animals also decreased the amplitude of the monosynaptic reflex (20–50% of controls). Sernylan decreased both the spontaneous and stimulus driven response of interneurones located in the dorsal horn of L7. Neither Renshaw cell activity nor Renshaw cell inhibition of the monosynaptic reflex was affected. Focal stimulation of the spinal cord in the motoneurone pool indicated that the response of motoneurones to direct electrical stimulation was unaffected by the drug, whereas the response attributed to antidromic stimulation of Ia afferent fibres was decreased by Sernylan (1–2 mgkg). It appears that Sernylan has its major effect on the spino-bulbo-spinal reflex at the input side (spino-bulbo). It also appears that the drug does not affect the monosynaptic reflex by tonic inhibition or disfacilitation of the motoneurones or by the mechanism of presynaptic inhibition, but by direct action on the membrane of Ia fibres or at the Ia- α motoneurone synapse.

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