The effects in vitro of 1-(1-phenylcyclohexyl) piperidine hydrochloride (sernyl) on oxidation by liver homogenates and mitochondria of rat☆

Add time:08/29/2019    Source:sciencedirect.com

A study of the effects in vitro of 1-(1-phenylcyclohexyl)piperidine·HCl (Sernyl) has shown that with succinate, α-ketoglutarate, β-hydroxybutyrate, or citrate as the substrate, the oxygen uptake by homogenates of rat liver was stimulated by 0·2 and 0·5 mM concentrations of the drug. Experiments with mitochondria gave similar results with succinate and α-ketoglutarate. Using the first three substrates or ferrocytochrome c, oxidative phosphorylation was uncoupled slightly by 0·1 mM and more markedly by 0·5 mM Sernyl. Mitochondrial swelling in 0·125 M KCl-0·02 M Tris: HCl buffer, pH 7·4, was enhanced by 0·1 mM Sernyl.A comparison of the effects of some analogs of the drug on the oxidation of succinate by liver homogenates showed that N-ethyl-1-cyclohexylcyclohexylamine·HCl and N-ethyl-1-phenylcyclohexylamine·HCl also had a stimulatory effect but less than that of Sernyl. No significant effect was shown by N-ethylcyclohexylamine·HCl, N-ethylpiperidine·HCl, or N-cyclohexylpiperidine·HCl.

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