Research paperGrowth of human herpesvirus 6 in HEPG2 cells

Add time:08/25/2019    Source:sciencedirect.com

HepG2 cells, a well differentiated liver cell line, were shown to be permissive for both human herpesvirus 6 (HHV-6) A and B strains by three independent methods of analysis: detection of viral antigens, viral DNA sequences and infectious virus. HepG2 cell infection with HHV-6 resulted in functional damage as shown by the increased release in the culture medium of some hepatocyte markers. Cells surviving the acute infection were serially passaged without showing cytopathic effect, but, some months later, HHV-6 DNA was still present in the cells and virus induction with a phorbol ester was successful. A possible pathogenetic role of HHV-6 in liver diseases is discussed. Experiments of HepG2 infection with human herpesvirus 7 (HHV-7) were also carried out. The lack of an efficient virus replication suggested a difficulty for HHV-7 to infect hepatic cells.

We also recommend Trading Suppliers and Manufacturers of human herpesvirus 6 p41 protein (cas 138415-18-6). Pls Click Website Link as below: cas 138415-18-6 suppliers

Prev:The effect of human herpesvirus 6B infection on the MAPK pathway
Next:Generation and characterization of a monoclonal antibody specific for human herpesvirus 6 variant A immediate–early 2 protein)