Chapter 9 Proteins of human herpesvirus-6

Add time:08/30/2019    Source:sciencedirect.com

Publisher SummaryThis chapter illustrates the available information about HHV-6 proteins. With an estimated 170 kb DNA, HHV-6 should code for more than 70 proteins. Even though only a limited number of papers have been published on HHV-6 proteins, comparison of the reported molecular weights of HHV-6 proteins is hampered by the use of different gel systems and different strains of HHV-6. Shiraki et al. (1989) have analyzed the virion proteins of the HHV-6-related isolate HST from exanthem subitum, and have identified at least 29 polypeptides ranging from 280k–30k. Among these are the 225k, 120–110k, 84–76k, 70–65k, 60k, and 53k. The information generated will allow establishing the role of viral proteins in the replicative cycle of virus, virus infection, latency, and other functions that will eventually give a better understanding of this new member of the herpesvirus family and will open up approaches to control HHV-6 infections.

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