A two-generation reproductive toxicity study of SODIUM MOLYBDATE (cas 12680-49-8) dihydrate administered in drinking water or diet to Sprague-Dawley rats

Add time:08/25/2019    Source:sciencedirect.com

In an OECD Test Guideline 416 multigenerational study, groups of 24 male and 24 female Sprague-Dawley rats were administered SODIUM MOLYBDATE (cas 12680-49-8) dihydrate at 0, 5, 17, or 40 mg molybdenum (Mo)/kg bw/day in the drinking water or 40 mg Mo/kg bw/day in the diet over two generations to assess reproductive toxicity. No adverse effect on reproductive function was observed at any dose level in either generation as indicated by no significant dose-related effect on estrus cycles, sperm parameters, mating, fertility, gestation, litter size, pup survival, growth or postnatal development. Systemic toxicity, including decreased body weight, food consumption (males only) and water consumption, was observed among both sexes given 40 mg Mo/kg bw/day in the diet. Serum levels of Mo and copper were increased in a dose-related manner. The No Observed Adverse Effect Levels (NOAEL) are 17 mg Mo/kg bw/day for systemic toxicity and 40 mg Mo/kg bw/day for reproductive toxicity.

We also recommend Trading Suppliers and Manufacturers of SODIUM MOLYBDATE (cas 12680-49-8). Pls Click Website Link as below: cas 12680-49-8 suppliers

Prev:Crystallization of SODIUM MOLYBDATE (cas 12680-49-8)-phosphate and tungstate-phosphate glasses
Next:Removal of tungsten from the SODIUM MOLYBDATE (cas 12680-49-8) solution using nascent MnO2)