Cas cliniqueAggravation apparente d’un psoriasis révélant un surdosage en méthotrexateApparent worsening of psoriasis lesions revealing methotrexate overdosage
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Add time:08/30/2019 Source:sciencedirect.com
RésuméIntroductionLe méthotrexate (MTX) est un antimétabolite utilisé dans le traitement de certains cancers, de maladies auto-immunes et, très couramment en dermatologie, du psoriasis cutané ou articulaire. Les toxicités secondaires à un surdosage en MTX sont essentiellement cutanée, hépatique et hématologique. Nous avons observé un patient chez qui un surdosage en MTX s’est manifesté par une poussée inflammatoire érosive de plaques de psoriasis préexistantes et l’apparition de nouvelles lésions sur les paumes.
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