A high speed parallel synthesis of 1,2-diaryl-1-ethanones via a clean-chemistry C–C bond formation reaction☆

Add time:08/24/2019    Source:sciencedirect.com

In this report, we describe the parallel as well as conventional synthesis of 1,2-diaryl-1-ethanones via environmentally benign acylation of arenes with in situ generated arylacetyl trifluoroacetates. A wide variety of arylacetic acids I participated in trifluoroacetic anhydride/ phosphoric acid mediated C–C bond formation reaction when reacted with arenes of type II to give 1,2-diaryl-1-ethanones III in good to excellent yield. Under the solvent-free conditions these chemical transformations that normally require longer reaction time can be performed within minutes in good yield.

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