An approach to the highly stereocontrolled synthesis of α-glycosides. Compatible use of the very acid labile dimethoxytrityl protecting group with Yb(OTf)3-promoted glycosidation☆

Add time:08/30/2019    Source:sciencedirect.com

The very acid labile dimethoxytrityl group is demonstrated to survive Yb(OTf)3-promoted glycosidations with N-phenyl trifluoroacetimidates as the donors. In addition, the installation of this sterically demanding protecting group at the primary position of the donor allows the achievement of a very high selectivity in the synthesis of α-glycosides with a variety of saccharidic acceptors.

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