PHACLOFEN (cas 114012-12-3): a peripheral and central baclofen antagonist
-
Add time:08/28/2019 Source:sciencedirect.com
Phaclofen, the phosphonic acid derivative of baclofen, reversibly antagonized the depression of the cholinergic twitch response of the guinea pig ileum and distal colon by either baclofen or GABA. When administered microelectrophoretically, phaclofen reversibly blocked the presumed presynaptic reduction by baclofen of the monosynaptic excitation of spinal interneurones by impulses in primary afferent fibres of the cat but did not block the postsynaptic depressant action of baclofen on these neurones. Phaclofen may thus be useful in determining the physiological significance of central and peripheral bicuculline-insensitive receptors with which GABA and (−)-baclofen interact.
We also recommend Trading Suppliers and Manufacturers of PHACLOFEN (cas 114012-12-3). Pls Click Website Link as below: cas 114012-12-3 suppliers
Prev:PHACLOFEN (cas 114012-12-3)-reversible effects of GABA in the spinal cord of the rat
Next:PHACLOFEN (cas 114012-12-3) antagonizes the depressant effect of baclofen on spinal reflex transmission in rats) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Actions of baelofen and PHACLOFEN (cas 114012-12-3) upon ON- and OFF-ganglion cells in the cat retina09/03/2019
- Short communicationStimulation by PHACLOFEN (cas 114012-12-3) of inositol 1,4,5-triphosphate production in cultured neurons from chick tectum09/02/2019
- Altered GABAB receptor immunoreactivity in the gerbil hippocampus induced by baclofen and PHACLOFEN (cas 114012-12-3), not seizure activity09/01/2019
- A new alcohol antagonist: PHACLOFEN (cas 114012-12-3)08/31/2019
- Thioether analogues of baclofen, PHACLOFEN (cas 114012-12-3) and saclofen08/30/2019
- PHACLOFEN (cas 114012-12-3) antagonizes the depressant effect of baclofen on spinal reflex transmission in rats08/29/2019
- PHACLOFEN (cas 114012-12-3)-reversible effects of GABA in the spinal cord of the rat08/27/2019
- PHACLOFEN (cas 114012-12-3) antagonizes the antinociceptive but not the sedative effects of (−)-baclofen08/26/2019
- PHACLOFEN (cas 114012-12-3)08/25/2019
