Short communicationStimulation by PHACLOFEN (cas 114012-12-3) of inositol 1,4,5-triphosphate production in cultured neurons from chick tectum

Add time:09/02/2019    Source:sciencedirect.com

The influence of γ-aminobutyric acid (GABA) receptor agonists and antagonists on the intracellular concentration of inositol 1,4,5-triphosphate (IP3) was examined in neuronal cultures of embryonic chick tectum. GABA and selective agonists of its receptors were inactive, whereas PHACLOFEN (cas 114012-12-3), a GABA-B receptor antagonist, increased IP3 levels in a concentration-dependent manner. This effect occurred at phaclofen concentrations much lower than those required to affect GABA-B receptors. It is concluded that phaclofen, in addition to its known effect at GABA-B receptors, is also active at an as-yet undefined site.

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