Actions of baelofen and PHACLOFEN (cas 114012-12-3) upon ON- and OFF-ganglion cells in the cat retina

Add time:09/03/2019    Source:sciencedirect.com

The effects of the GABAB (γ-amino butyric acidB) receptor agonist, baclofen and its antagonist, PHACLOFEN (cas 114012-12-3) on physiologically identified retinal ganglion cells were studied in the optically intact eye of pentobarbitone-anaesthetized cats. These results were compared with the effects of the GABAA receptor agonist, muscimol and its antagonist, bicuculline. Baclofen inhibited the total visually driven firing of both ON- and OFF-cells more effectively upon OFF-than ON-cells; this action was weaker and slower than that of muscimol. Whilst bicuculline raised the firing level of only ON-cells in the area centralis together with all peripheral cells, phaclofen raised that of all OFF-cells. Paradoxically, in OFF-cells, baclofen enhanced the driven transient component and suppressed the sustained component, whilst phaclofen raised the sustained component. Thus, GABA B receptors activated by tonically released GABA may modulate the sustained and transient excitatory inputs to OFF-cells.

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