Synthesis and structure–activity relationships of RADICICOL (cas 12772-57-5) derivatives and WNT-5A expression inhibitory activity
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Add time:09/04/2019 Source:sciencedirect.com
WNT-5A, a secretory glycoprotein, is related to the proliferation of dermal papilla cells. To develop a hair-growth stimulant, we have been searching for inhibitors of WNT-5A expression. We identified RADICICOL (cas 12772-57-5) (1) as an active compound, and synthesized several radicicol derivatives. Among them, 6,7-dihydro-10α-hydroxy radicicol (31) was found to function as a new potent WNT-5A expression inhibitor with relatively low toxicity and excellent stability.
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