Subchapter 18D - Pituitary Adenylate Cyclase-Activating Polypeptide-Related Peptide

Add time:09/06/2019    Source:sciencedirect.com

Pituitary adenylate cyclase-activating polypeptide-related peptide (PRP), also named GHRH-like peptide, was identified as a structurally related peptide of PACAP on the PACAP precursor. PRP and PRP-like peptides were identified in vertebrates and tunicates. Mammalian PRP peptides are 29 aa residues in length, non-mammalian PRP peptides 43–46 aa, and tunicate PRP-like peptides 27 aa. PRP/PACAP precursor is detected most abundantly in the central nervous tissues, especially in the hypothalamus. The PRP receptor, formerly referred to as the GHRH receptor, is a G protein-coupled receptor with a seven transmembrane helical domain. Although a receptor highly specific for PRP has been characterized in non-mammals, a specific receptor for PRP has not been isolated in any mammalian species. PRP receptor mRNA was widely detected in brain, pituitary, and peripheral tissues. PRP has potential to stimulate GH release from anterior pituitary cells, but the potency is lower in the chicken and lost in mammals.

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