A novel product from Beckmann rearrangement of erythromycin A 9(E)-oxime
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Add time:09/04/2019 Source:sciencedirect.com
Beckmann rearrangement of erythromycin A 9(E)-oxime with toluenesulfonyl chloride in ethyl ether at −45°C generates 9,11-imino ether IV which leads to azithromycin. The 9,11-imino ether can also be readily obtained from isomerization of its isomer 6,9-imino ether III.
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