Synthesis of optically active trifluoromethyl-substituted 2,3-dihydroimidazo[2,1-b]oxazoles

Add time:07/14/2019    Source:sciencedirect.com

The 2-unsubstituted imidazole N-oxides with a 3,3,3-trifluoro-2-hydroxypropyl group at N(1) in the presence of acetic anhydride undergo cyclization via the intramolecular nucleophilic attack of the hydroxyl group onto C(2) of the imidazole ring to give trifluoromethylated derivatives of 2,3-dihydroimidazo[2,1-b]oxazoles. This method, starting with enantiopure substrates, allows the preparation of enantiopure products in a one-pot procedure.

We also recommend Trading Suppliers and Manufacturers of 1-[3-(Trifluoromethyl)phenyl]-1H-imidazole-4-carboxylic acid (cas 445302-16-9). Pls Click Website Link as below: cas 445302-16-9 suppliers

Prev:The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain
Next:Access to novel amino trifluoromethyl cyclopropane carboxylic acid derivatives)