Access to novel amino trifluoromethyl cyclopropane carboxylic acid derivatives

Add time:07/15/2019    Source:sciencedirect.com

Novel regioisomers of trifluoromethylated cyclopropanes have been synthesized by Michael addition and nucleophilic cyclization process. The reaction was carried out with the trifluoromethylcrotonate 6 and nucleophilic reagents. Fluorinated cyclopropanes were obtained with good to excellent diastereoselectivities. Furthermore, interesting constrained building blocks have emerged from this methodology.

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