In(OTf)3/acid co-catalyzed hydration of 1-haloalkynes to α-halomethyl ketones

Add time:09/02/2019    Source:sciencedirect.com

A novel and efficient In(OTf)3 and HOAc cooperatively catalyzed hydration of 1-haloalkynes is described. This method provides ready access to α-chloromethyl ketones, α-bromomethyl ketones and α-iodomethyl ketones in moderate to high yields from simple, inexpensive starting materials. A broad substrate scope is achieved, and the reaction is compatible with various functional groups, including alkoxy, trifluoromethyl, halide, hydroxyl, cyclohexyl, and heterocyclic groups.

We also recommend Trading Suppliers and Manufacturers of CYCLOHEXYL 2-METHOXYPHENYL KETONE (cas 111504-19-9). Pls Click Website Link as below: cas 111504-19-9 suppliers

Prev:Copper-catalyzed asymmetric tandem double Michael reactions of diethylzinc to α,β-unsaturated ketones followed by trapping with nitroolefins
Next:Chemoselective hydrogenation of aromatic ketones with Pt-based heterogeneous catalysts. Substituent effects)