Dose dependent acute toxicity of Abrin (cas 1393-62-0) in Balb/c mice after intraperitoneal administration
-
Add time:09/01/2019 Source:sciencedirect.com
Abrin (cas 1393-62-0) toxin is one of the most potent and deadly plant toxin obtained from the seeds of Abrus precatorious. It is more toxic than ricin which is classified as Schedule 1 agent by OPCW and Category B bioterrorism agent by Centre for Disease Control (CDC). Dose dependent acute toxicity of abrin is still a matter of investigation. The present study was carried out to assess the toxicity of abrin from sub lethal to supralethal doses (0.5X, 1X, 2X and 5XLD50) after intraperitoneal administration. After 8 and 24h of abrin exposure, hematological, biochemical, inflammatory and oxidative stress associated parameters were analyzed. Liver histology was also done to analyze the effect of abrin. Abrin exerts its toxicity in a dose and time dependent manner. Increases in neutrophil counts, lipid peroxidation with decreased lymphocyte counts, are the initiating factor irrespective of time and dose. At higher doses of abrin there was a decrease in hemoglobin level and RBC count which is reflected by increased levels of serum ammonia and bilirubin. Neutrophil infiltration in the liver and lipid peroxidation cause liver toxicity (increased production of ALT and ALP); oxidative stress (depletion of GSH and total antioxidant status); inflammation (increased production of TNF-α and IFN-γ). Further, at higher doses of abrin, intensity of oxidative stress, inflammation and liver toxicity are more pronounced which may have been maintained by the self-sustaining loop of toxicity leading to death of the animals.
We also recommend Trading Suppliers and Manufacturers of Abrin (cas 1393-62-0). Pls Click Website Link as below: cas 1393-62-0 suppliers
Prev:Anion recognition by THIOSTREPTON (cas 1393-48-2)
Next:Integration of transcriptomics, proteomics and metabolomics data to reveal the biological mechanisms of Abrin (cas 1393-62-0) injury in human lung epithelial cells) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Antibody treatment against pulmonary exposure to Abrin (cas 1393-62-0) confers significantly higher levels of protection than treatment against ricin intoxication09/09/2019
- Trace level detections of Abrin (cas 1393-62-0) with high SNR piezoresistive cantilever biosensor09/08/2019
- The analysis of Abrin (cas 1393-62-0) in food and beverages09/07/2019
- Chemical terrorismRicin and Abrin (cas 1393-62-0)09/06/2019
- Evaluation of Abrin (cas 1393-62-0) induced nephrotoxicity by using novel renal injury markers09/05/2019
- A chimeric protein of Abrin (cas 1393-62-0) and Abrus precatorius agglutinin that neutralizes Abrin (cas 1393-62-0) mediated lethality in mice09/04/2019
- Real-time and in-situ monitoring of Abrin (cas 1393-62-0) induced cell apoptosis by using SERS spectroscopy09/03/2019
- Integration of transcriptomics, proteomics and metabolomics data to reveal the biological mechanisms of Abrin (cas 1393-62-0) injury in human lung epithelial cells09/02/2019