Protection from ANTIMYCIN A (cas 1397-94-0)-induced mitochondrial dysfunction by Nelumbo nucifera seed extracts

Add time:09/07/2019    Source:sciencedirect.com

Antimycin A (AMA) damages the mitochondria through inhibition of mitochondrial electron transport. In this study, exposure of L6 rat skeletal muscle cells to AMA induced a decrease in ATP content, followed by a decrease in mitochondrial membrane potential, leading to apoptosis. We evaluated the protective effects of water and ethanol extracts of Nelumbo nucifera seeds on L6 cells with AMA-induced oxidative stress. We found that the extracts reduced cellular apoptosis; preserved the mitochondrial membrane potential; protected mitochondrial ATP production; inhibited p53, Bax, and caspase 3 activities; and induced Bcl-2 production. Our results suggested that AMA induced apoptosis in L6 cells via impairment of mitochondrial function. N. nucifera extracts protected the cells from this mitochondria-mediated cell death.

We also recommend Trading Suppliers and Manufacturers of ANTIMYCIN A (cas 1397-94-0). Pls Click Website Link as below: cas 1397-94-0 suppliers

Prev:ANTIMYCIN A (cas 1397-94-0) induces apoptosis in As4.1 juxtaglomerular cells
Next:How does antimycin inhibit the bc1 complex? A part-time twin)