Actinomycins

Add time:09/07/2019    Source:sciencedirect.com

Publisher SummaryThis chapter discusses actinomycins, focusing on their production, therapeutic use and pharmacology, as well as their extraction, separation, and purification. The actinomycins are a series of chromopeptide lactone antibiotics with a common structural format differing only in certain amino acid residues. Separation of mixtures of such closely-related compounds represents a formidable task. Partition chromatography has in general proved more useful than adsorption chromatography, particularly in the separation of components differing only in alkylside chains. The recovery of actinomycins from culture filtrates after fermentations has usually been effected by extraction with organic solvents, such as ethyl acetate or butyl acetate. The techniques used for partition chromatographic separations of actinomycin mixtures on cellulose powder columns follow the same principles as those applied to paper chromatography (PC). The general observations made above concerning adsorption chromatography apply also to the use of silicic acid, which has been employed both for purification, and in some cases, for separation of actinomycin mixtures.

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