Synthesis, crystal structure, and absolute configuration of the enantiomers of chiral drug xibenolol hydrochloride

Add time:09/05/2019    Source:sciencedirect.com

Based on the features of its crystallization, racemic 3-(2,3-dimethylphenoxy)propane-1,2-diol 2, the synthetic precursor of the chiral drug xibenolol 1, was resolved into pure enantiomers by the direct method of entrainment. The enantiomers of diol 2 through a Mitsunobu reaction were converted into the nonracemic 1,2-epoxy-3-(2,3-dimethylphenoxy)propanes (S)- and (R)-3, and then into the xibenolol enantiomers. Single crystals of (+)- and (−)-1·HCl were studied by X-ray diffraction. On the basis of the Flack parameter, the absolute (R)- and (S)-configurations were assigned to these compounds and to the other intermediate chiral substances.

We also recommend Trading Suppliers and Manufacturers of TRIPHENYLPHOSPHINE HYDROCHLORIDE (cas 15647-89-9). Pls Click Website Link as below: cas 15647-89-9 suppliers

Prev:Synthesis, structural characterization and radiochemistry of di- and tricarbonyl Re(I) and 99mTc(I) complexes with 8-hydroxyquinoline or 8-mercaptoquinoline and triphenylphosphine
Next:Synthesis, crystal growth and characterization of a chiral compound (triphenylphosphine oxide cadmium iodide): A new semiorganic nonlinear optical material)