Ugi reaction for the synthesis of 4-Aminopiperidine (cas 13035-19-3)-4-carboxylic acid derivatives. Application to the synthesis of carfentanil and remifentanil

Add time:09/06/2019    Source:sciencedirect.com

A two-step sequence involving an Ugi four-component reaction was developed for the preparation of 4-aminopiperidine-4-carboxylic acid derivatives. This strategy has led to the successful preparation of two drugs carfentanil and remifentanil in shorter times and better yields than previously described methods.

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