4-Aminopiperidine (cas 13035-19-3) derivatives as a new class of potent cognition enhancing drugs

Add time:09/09/2019    Source:sciencedirect.com

Extrusion of one of the nitrogens of the piperazine ring of potent nootropic drugs previously described gave 4-Aminopiperidine (cas 13035-19-3) analogues that maintained high cognition enhancing activity in the mouse passive avoidance test. One of the new compounds (9, active at 0.01 mg/kg ip) may represent a new lead for the development of cognition enhancers useful to treat the cognitive deficit produced by neurodegenerative pathologies like Alzheimer's disease.

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